The Bio-Psychosocial-Spiritual (BPSS) model is a comprehensive approach that recognises the dynamic interplay between biological, psychological, social, and spiritual domains in influencing health outcomes and patient well-being. Although the BPSS model is widely used in clinical practice for holistic patient care, it remains underutilised in Clinical Ethics Committee (CEC) consultations. Drawing on a case from the National Cancer Centre Singapore CEC, this presentation demonstrates how systematically applying the BPSS model enhances CEC practice by providing key advantages. Rather than approaching cases ad hoc, the BPSS model guides CECs to systematically examine all four domains, reducing incomplete analysis and uncovering underlying factors driving ethical conflicts. Additionally, it provides common language and structure for discussions, improving deliberative quality and efficiency while reducing ambiguity about the necessary considerations. By examining how biological, psychological, social, and spiritual factors shape stakeholder perspectives, the model promotes deeper understanding of diverse viewpoints. Significantly, the BPSS model facilitates a paradigmatic shift from problem-focused to person-centred analysis, making contributions from non-medical professionals such as social workers essential rather than supplementary, thereby promoting effective interdisciplinary collaboration. For optimal implementation, the BPSS model should be used as an assessment tool rather than a decision-making mechanism and integrated with other ethical frameworks for case resolution; this process is most effective when facilitated by practitioners familiar with the model. This approach demonstrates how established models, when appropriately implemented by CECs, ultimately enable more systematic and holistic case consultations.